Nature Communications (Mar 2023)
SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry
- Bieke Decaesteker,
- Amber Louwagie,
- Siebe Loontiens,
- Fanny De Vloed,
- Sarah-Lee Bekaert,
- Juliette Roels,
- Suzanne Vanhauwaert,
- Sara De Brouwer,
- Ellen Sanders,
- Alla Berezovskaya,
- Geertrui Denecker,
- Eva D’haene,
- Stéphane Van Haver,
- Wouter Van Loocke,
- Jo Van Dorpe,
- David Creytens,
- Nadine Van Roy,
- Tim Pieters,
- Christophe Van Neste,
- Matthias Fischer,
- Pieter Van Vlierberghe,
- Stephen S. Roberts,
- Johannes Schulte,
- Sara Ek,
- Rogier Versteeg,
- Jan Koster,
- Johan van Nes,
- Mark Zimmerman,
- Katleen De Preter,
- Frank Speleman
Affiliations
- Bieke Decaesteker
- Department of Biomolecular medicine, Ghent University
- Amber Louwagie
- Department of Biomolecular medicine, Ghent University
- Siebe Loontiens
- Department of Biomolecular medicine, Ghent University
- Fanny De Vloed
- Department of Biomolecular medicine, Ghent University
- Sarah-Lee Bekaert
- Department of Biomolecular medicine, Ghent University
- Juliette Roels
- Department of Biomolecular medicine, Ghent University
- Suzanne Vanhauwaert
- Department of Biomolecular medicine, Ghent University
- Sara De Brouwer
- Department of Biomolecular medicine, Ghent University
- Ellen Sanders
- Department of Biomolecular medicine, Ghent University
- Alla Berezovskaya
- Department of Pediatric Oncology, Dana-Farber Cancer Institute
- Geertrui Denecker
- Department of Biomolecular medicine, Ghent University
- Eva D’haene
- Department of Biomolecular medicine, Ghent University
- Stéphane Van Haver
- Department of Biomolecular medicine, Ghent University
- Wouter Van Loocke
- Department of Biomolecular medicine, Ghent University
- Jo Van Dorpe
- Cancer Research Institute Ghent (CRIG)
- David Creytens
- Cancer Research Institute Ghent (CRIG)
- Nadine Van Roy
- Department of Biomolecular medicine, Ghent University
- Tim Pieters
- Department of Biomolecular medicine, Ghent University
- Christophe Van Neste
- Department of Biomolecular medicine, Ghent University
- Matthias Fischer
- Department for Experimental Pediatric Oncology, and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne
- Pieter Van Vlierberghe
- Department of Biomolecular medicine, Ghent University
- Stephen S. Roberts
- Department of Pediatrics, Memorial Sloan Kettering Cancer Center
- Johannes Schulte
- Department of Pediatric Oncology and Hematology, Charité-Universitätsmedizin Berlin
- Sara Ek
- Department of Immunotechnology, Lund University
- Rogier Versteeg
- Department of Oncogenomics, Academic Medical Center
- Jan Koster
- Department of Oncogenomics, Academic Medical Center
- Johan van Nes
- Department of Oncogenomics, Academic Medical Center
- Mark Zimmerman
- Department of Pediatric Oncology, Dana-Farber Cancer Institute
- Katleen De Preter
- Department of Biomolecular medicine, Ghent University
- Frank Speleman
- Department of Biomolecular medicine, Ghent University
- DOI
- https://doi.org/10.1038/s41467-023-36735-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
The development of neuroblastoma (NB) is regulated by multiple core transcription factors. Here, SOX11 is identified as a potential epigenetic master regulator upstream of the core regulatory circuitry in adrenergic high-risk neuroblastoma.
