Nature Communications (2019-03-01)

Bacterial AB5 toxins inhibit the growth of gut bacteria by targeting ganglioside-like glycoconjugates

  • Robert T. Patry,
  • Martin Stahl,
  • Maria Elisa Perez-Munoz,
  • Harald Nothaft,
  • Cory Q. Wenzel,
  • Jessica C. Sacher,
  • Colin Coros,
  • Jens Walter,
  • Bruce A. Vallance,
  • Christine M. Szymanski

DOI
https://doi.org/10.1038/s41467-019-09362-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Bacterial AB5 toxins, such as cholera toxin, bind to oligosaccharides on the host cell surface and play key roles in the pathogenesis of diarrheal disease. Here, Patry et al. show that these toxins bind also to bacterial oligosaccharides and inhibit the growth of Campylobacter jejuni and gut commensal bacteria.