Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia

Sathiyanarayanan Manivannan; Corrin Mansfield; Xinmin Zhang; Karthik M. Kodigepalli; Uddalak Majumdar; Vidu Garg; Madhumita Basu

doi:10.1038/s42003-022-03779-x

Communications Biology (Aug 2022)

Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia

Sathiyanarayanan Manivannan,
Corrin Mansfield,
Xinmin Zhang,
Karthik M. Kodigepalli,
Uddalak Majumdar,
Vidu Garg,
Madhumita Basu

Affiliations

Sathiyanarayanan Manivannan: Center for Cardiovascular Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital
Corrin Mansfield: Center for Cardiovascular Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital
Xinmin Zhang: BioInfoRx Inc.
Karthik M. Kodigepalli: Department of Pediatrics, Medical College of Wisconsin
Uddalak Majumdar: Center for Cardiovascular Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital
Vidu Garg: Center for Cardiovascular Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital
Madhumita Basu: Center for Cardiovascular Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital

DOI: https://doi.org/10.1038/s42003-022-03779-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 21

Abstract

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ScRNA-seq of embryonic heart tissues from a mouse model of maternal hyperglycemia (matHG) provides further insight into how matHG disrupts heart development and perturbs second heart field derived cardiomyocyte differentiation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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