Angiopoietin-1 promotes triple-negative breast cancer                     cell proliferation by upregulating carboxypeptidase A4

Liu Xue; Liang Huichun; Fang Huan; Xiao Ji; Yang Chuanyu; Zhou Zhongmei; Feng Jing; Chen Ceshi

doi:10.3724/abbs.2023082

Acta Biochimica et Biophysica Sinica (May 2023)

Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4

Liu Xue,
Liang Huichun,
Fang Huan,
Xiao Ji,
Yang Chuanyu,
Zhou Zhongmei,
Feng Jing,
Chen Ceshi

Affiliations

Liu Xue: ["Medical College, Anhui University of Science and Technology, Huainan 232001, China","Department of Laboratory Medicine & Central Laboratory, Fengxian District Central Hospital of Shanghai, Shanghai 201499, China","Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"]
Liang Huichun: ["Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"]
Fang Huan: ["Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"]
Xiao Ji: ["College of Life Science and Technology, Guangzhou Jinan Biomedicine Research and Development Center, Jinan University, Guangzhou 510632, China"]
Yang Chuanyu: ["Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China"]
Zhou Zhongmei: ["The School of Continuing Education, Kunming Medical University, Kunming 650500, China"]
Feng Jing: ["Department of Laboratory Medicine & Central Laboratory, Fengxian District Central Hospital of Shanghai, Shanghai 201499, China","The Second Affiliated Hospital of the Chinese University of Hong Kong, Shenzhen 518172, China"]
Chen Ceshi: ["Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China","Academy of Biomedical Engineering, Kunming Medical University, Kunming 650500, China","The Third Affiliated Hospital, Kunming Medical University, Kunming 650106, China"]

DOI: https://doi.org/10.3724/abbs.2023082
Journal volume & issue: Vol. 55
pp. 1487 – 1495

Abstract

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Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.

Published in Acta Biochimica et Biophysica Sinica

ISSN: 1672-9145 (Print); 1745-7270 (Online)
Publisher: China Science Publishing & Media Ltd.
Country of publisher: China
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (General): Genetics
Website: https://www.sciengine.com/ABBS/home

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