The Correlation between Inflammatory Biomarkers andLung Function in COPD Stable Phase

Abstract

Objective To investigate the correlation between interleukin(IL) -1 family, classical inflammatory markers and pulmonary function in patients with stable chronic obstructive pulmonary disease(COPD). Methods Forty-five patients with stable COPD who visited the outpatient clinic or ward of the Department of Geriatrics,Beijing Jishuitan Hospital,Capital Medical University,from July 2021 to December 2022 were selected for a prospective cross-sectional survey to collect gender,age,smoking history and smoking index,underlying disease information,and serum IL-1 family(IL-1α,IL-1β,IL-18),IL-6,IL-8,TNF-α detection and pulmonary function tests. Results Multivariate regression analysis found that IL-18 was independently correlated with forced expiratory volume in the first second(FEV1) predicted value(FEV1%),IL-18 and age were independently associated with the single-breath diffusing lung capacity of carbon monoxide(DLCO),IL-18 was independently related to the improvement rate of FEV1. Conclusion IL-18 level in stable COPD was significantly correlated with pulmonary ventilation function,pulmonary diffusion capacity and FEV1 improvement rate,which suggesting that IL-18 may play an important role in the development of the disease at this stage and can be used as the good monitoring indicators for the evaluation of stable COPD.

Keywords

• chronic obstructive pulmonary disease
• stable phase
• il-1 family
• inflammatory factors
• pulmonary function