The influence of hormonal status on the hepatotropic effect and metronidazole in chronic liver damage and the administration of placenta cryoextract

Abstract

Background. Liver diseases occupy an important place in the structure of gastrointestinal pathology and remain an important medical and social problem throughout the world. Almost half of patients with manifest disorders of the hepatobiliary system have a polymorbid status or a high risk of developing concomitant pathology. One of the variants of the combined pathology in the clinic of gastroenterology is peptic ulcer on the background of liver disorders. As a potential anti-ulcer biotechnological agent with a hepatoprotective effect, cryocell — placenta cryoextract, a domestic drug, attracted attention. The purpose was to determine the gender aspects of the hepatotropic effect of placenta cryoextract in tetrachloromethane hepatitis with background ethanol-induced liver cirrhosis and liver damage by antiulcer agents. Materials and methods. Hepatotropic effects were studied at different levels of sex hormones in 112 male and female rats weighing 200–220 g, divided into 4 groups of 28 animals each. Tetrachloromethane hepatitis with background ethanol-induced liver cirrhosis was simulated by administration of an oily solution of tetrachloromethane in combination with a 5.0% ethanol solution for 45 days. Modulation of the content of sex hormones was achieved by surgical ovariectomy or orchiectomy. The activity of γ-glutamyl-transpeptidase was determined by the spectrophotometric method according to G. Szasz.

Keywords

• cryopreserved placenta extract
• antiulcer drugs
• drug-induced liver damage
• tetrachloromethane hepatitis
• cytolysis