Clinical Interventions in Aging (Sep 2019)
LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
Abstract
Haotao Yu, Wei Zhou, Weiming Yan, Zhongqi Xu, Yinhao Xie, Ping Zhang Department of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaCorrespondence: Ping ZhangDepartment of Orthopedics, Division 1, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Street, Liwan District, Guangzhou City, Guangdong Province 510000, People’s Republic of ChinaTel/Fax +86 0 208 134 6935Email [email protected]: In this study, we aimed to investigate the role of lncRNA cancer susceptibility 11 (CASC11) and tumor necrosis factor (TNF-α) in postmenopausal osteoporosis (POP).Methods and materials: POP patients and healthy controls were included in this study and levels of CASC11 and TNF-α in plasma of those participants were measured by qPCR and Western blot, respectively. ROC curve was used for diagnostic analysis. Patients were followed up for 2 years and the correlations between the levels of CASC11 and TNF-α and disease conditions were analyzed.Results: We found that CASC11 and TNF-α were both upregulated in plasma of POP patients than in healthy controls. Plasma levels of CASC11 and TNF-α were positively correlated in both POP patients and in healthy controls. Upregulation of CASC11 and TNF-α distinguished POP patients from healthy controls. Treatment and follow-up study showed that high CASC11 levels were significantly correlated with prolonged treatment course and high recurrence rate. Plasma levels of CASC11 and TNF-α decreased after treatment. CASC11 overexpression led to upregulated TNF-α in osteoclasts.Conclusion: CASC11 is upregulated in POP and is correlated with TNF-α.Keywords: postmenopausal osteoporosis, CASC11, TNF-α, osteoclasts
