Frontiers in Chemistry (Jan 2022)

Synthesis of N-Heteroarenemethyl Esters via C–C Bond Cleavage of Acyl Cyanides Under Transition Metal-Free Conditions

  • Miao Lai,
  • Fangyao Su,
  • Jingyi Hu,
  • Mengzhuo Wang,
  • Mingqin Zhao,
  • Ganlin Zhang

DOI
https://doi.org/10.3389/fchem.2021.822625
Journal volume & issue
Vol. 9

Abstract

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A practical method to synthesize N-heteroaryl esters from N-heteroaryl methanols with acyl cyanides via C–C bond cleavage without using any transition metal is demonstrated here. The use of Na2CO3/15-crown-5 couple enables access to a series of N-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts.

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