Nature Communications (Jan 2019)
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- Tuomas O. Kilpeläinen,
- Amy R. Bentley,
- Raymond Noordam,
- Yun Ju Sung,
- Karen Schwander,
- Thomas W. Winkler,
- Hermina Jakupović,
- Daniel I. Chasman,
- Alisa Manning,
- Ioanna Ntalla,
- Hugues Aschard,
- Michael R. Brown,
- Lisa de las Fuentes,
- Nora Franceschini,
- Xiuqing Guo,
- Dina Vojinovic,
- Stella Aslibekyan,
- Mary F. Feitosa,
- Minjung Kho,
- Solomon K. Musani,
- Melissa Richard,
- Heming Wang,
- Zhe Wang,
- Traci M. Bartz,
- Lawrence F. Bielak,
- Archie Campbell,
- Rajkumar Dorajoo,
- Virginia Fisher,
- Fernando P. Hartwig,
- Andrea R. V. R. Horimoto,
- Changwei Li,
- Kurt K. Lohman,
- Jonathan Marten,
- Xueling Sim,
- Albert V. Smith,
- Salman M. Tajuddin,
- Maris Alver,
- Marzyeh Amini,
- Mathilde Boissel,
- Jin Fang Chai,
- Xu Chen,
- Jasmin Divers,
- Evangelos Evangelou,
- Chuan Gao,
- Mariaelisa Graff,
- Sarah E. Harris,
- Meian He,
- Fang-Chi Hsu,
- Anne U. Jackson,
- Jing Hua Zhao,
- Aldi T. Kraja,
- Brigitte Kühnel,
- Federica Laguzzi,
- Leo-Pekka Lyytikäinen,
- Ilja M. Nolte,
- Rainer Rauramaa,
- Muhammad Riaz,
- Antonietta Robino,
- Rico Rueedi,
- Heather M. Stringham,
- Fumihiko Takeuchi,
- Peter J. van der Most,
- Tibor V. Varga,
- Niek Verweij,
- Erin B. Ware,
- Wanqing Wen,
- Xiaoyin Li,
- Lisa R. Yanek,
- Najaf Amin,
- Donna K. Arnett,
- Eric Boerwinkle,
- Marco Brumat,
- Brian Cade,
- Mickaël Canouil,
- Yii-Der Ida Chen,
- Maria Pina Concas,
- John Connell,
- Renée de Mutsert,
- H. Janaka de Silva,
- Paul S. de Vries,
- Ayşe Demirkan,
- Jingzhong Ding,
- Charles B. Eaton,
- Jessica D. Faul,
- Yechiel Friedlander,
- Kelley P. Gabriel,
- Mohsen Ghanbari,
- Franco Giulianini,
- Chi Charles Gu,
- Dongfeng Gu,
- Tamara B. Harris,
- Jiang He,
- Sami Heikkinen,
- Chew-Kiat Heng,
- Steven C. Hunt,
- M. Arfan Ikram,
- Jost B. Jonas,
- Woon-Puay Koh,
- Pirjo Komulainen,
- Jose E. Krieger,
- Stephen B. Kritchevsky,
- Zoltán Kutalik,
- Johanna Kuusisto,
- Carl D. Langefeld,
- Claudia Langenberg,
- Lenore J. Launer,
- Karin Leander,
- Rozenn N. Lemaitre,
- Cora E. Lewis,
- Jingjing Liang,
- Lifelines Cohort Study,
- Jianjun Liu,
- Reedik Mägi,
- Ani Manichaikul,
- Thomas Meitinger,
- Andres Metspalu,
- Yuri Milaneschi,
- Karen L. Mohlke,
- Thomas H. Mosley,
- Alison D. Murray,
- Mike A. Nalls,
- Ei-Ei Khaing Nang,
- Christopher P. Nelson,
- Sotoodehnia Nona,
- Jill M. Norris,
- Chiamaka Vivian Nwuba,
- Jeff O’Connell,
- Nicholette D. Palmer,
- George J. Papanicolau,
- Raha Pazoki,
- Nancy L. Pedersen,
- Annette Peters,
- Patricia A. Peyser,
- Ozren Polasek,
- David J. Porteous,
- Alaitz Poveda,
- Olli T. Raitakari,
- Stephen S. Rich,
- Neil Risch,
- Jennifer G. Robinson,
- Lynda M. Rose,
- Igor Rudan,
- Pamela J. Schreiner,
- Robert A. Scott,
- Stephen S. Sidney,
- Mario Sims,
- Jennifer A. Smith,
- Harold Snieder,
- Tamar Sofer,
- John M. Starr,
- Barbara Sternfeld,
- Konstantin Strauch,
- Hua Tang,
- Kent D. Taylor,
- Michael Y. Tsai,
- Jaakko Tuomilehto,
- André G. Uitterlinden,
- M. Yldau van der Ende,
- Diana van Heemst,
- Trudy Voortman,
- Melanie Waldenberger,
- Patrik Wennberg,
- Gregory Wilson,
- Yong-Bing Xiang,
- Jie Yao,
- Caizheng Yu,
- Jian-Min Yuan,
- Wei Zhao,
- Alan B. Zonderman,
- Diane M. Becker,
- Michael Boehnke,
- Donald W. Bowden,
- Ulf de Faire,
- Ian J. Deary,
- Paul Elliott,
- Tõnu Esko,
- Barry I. Freedman,
- Philippe Froguel,
- Paolo Gasparini,
- Christian Gieger,
- Norihiro Kato,
- Markku Laakso,
- Timo A. Lakka,
- Terho Lehtimäki,
- Patrik K. E. Magnusson,
- Albertine J. Oldehinkel,
- Brenda W. J. H. Penninx,
- Nilesh J. Samani,
- Xiao-Ou Shu,
- Pim van der Harst,
- Jana V. Van Vliet-Ostaptchouk,
- Peter Vollenweider,
- Lynne E. Wagenknecht,
- Ya X. Wang,
- Nicholas J. Wareham,
- David R. Weir,
- Tangchun Wu,
- Wei Zheng,
- Xiaofeng Zhu,
- Michele K. Evans,
- Paul W. Franks,
- Vilmundur Gudnason,
- Caroline Hayward,
- Bernardo L. Horta,
- Tanika N. Kelly,
- Yongmei Liu,
- Kari E. North,
- Alexandre C. Pereira,
- Paul M. Ridker,
- E. Shyong Tai,
- Rob M. van Dam,
- Ervin R. Fox,
- Sharon L. R. Kardia,
- Ching-Ti Liu,
- Dennis O. Mook-Kanamori,
- Michael A. Province,
- Susan Redline,
- Cornelia M. van Duijn,
- Jerome I. Rotter,
- Charles B. Kooperberg,
- W. James Gauderman,
- Bruce M. Psaty,
- Kenneth Rice,
- Patricia B. Munroe,
- Myriam Fornage,
- L. Adrienne Cupples,
- Charles N. Rotimi,
- Alanna C. Morrison,
- Dabeeru C. Rao,
- Ruth J. F. Loos
Affiliations
- Tuomas O. Kilpeläinen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Amy R. Bentley
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Raymond Noordam
- Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center
- Yun Ju Sung
- Division of Biostatistics, Washington University School of Medicine
- Karen Schwander
- Division of Biostatistics, Washington University School of Medicine
- Thomas W. Winkler
- Department of Genetic Epidemiology, University of Regensburg
- Hermina Jakupović
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Daniel I. Chasman
- Preventive Medicine, Brigham and Women’s Hospital
- Alisa Manning
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital
- Ioanna Ntalla
- Clinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Hugues Aschard
- Department of Epidemiology, Harvard School of Public Health
- Michael R. Brown
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Lisa de las Fuentes
- Division of Biostatistics, Washington University School of Medicine
- Nora Franceschini
- Epidemiology, University of North Carolina Gillings School of Global Public Health
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Dina Vojinovic
- Department of Epidemiology, Erasmus University Medical Center
- Stella Aslibekyan
- Department of Epidemiology, University of Alabama at Birmingham
- Mary F. Feitosa
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Minjung Kho
- Department of Epidemiology, School of Public Health, University of Michigan
- Solomon K. Musani
- Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center
- Melissa Richard
- Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Heming Wang
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Zhe Wang
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Traci M. Bartz
- Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Archie Campbell
- Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh
- Rajkumar Dorajoo
- Genome Institute of Singapore, Agency for Science Technology and Research
- Virginia Fisher
- Biostatistics, Boston University School of Public Health
- Fernando P. Hartwig
- Postgraduate Program in Epidemiology, Federal University of Pelotas
- Andrea R. V. R. Horimoto
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Changwei Li
- Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health
- Kurt K. Lohman
- Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences
- Jonathan Marten
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Xueling Sim
- Saw Swee Hock School of Public Health, National University Health System and National University of Singapore
- Albert V. Smith
- Icelandic Heart Association
- Salman M. Tajuddin
- Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Maris Alver
- Estonian Genome Center, University of Tartu
- Marzyeh Amini
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Mathilde Boissel
- CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille
- Jin Fang Chai
- Saw Swee Hock School of Public Health, National University Health System and National University of Singapore
- Xu Chen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm
- Jasmin Divers
- Department of Biostatistical Sciences, Wake Forest School of Medicine
- Evangelos Evangelou
- Department of Epidemiology and Biostatistics, Imperial College London
- Chuan Gao
- Molecular Genetics and Genomics Program, Wake Forest School of Medicine
- Mariaelisa Graff
- Epidemiology, University of North Carolina Gillings School of Global Public Health
- Sarah E. Harris
- Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh
- Meian He
- Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology
- Fang-Chi Hsu
- Department of Biostatistical Sciences, Wake Forest School of Medicine
- Anne U. Jackson
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Jing Hua Zhao
- MRC Epidemiology Unit, University of Cambridge
- Aldi T. Kraja
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Brigitte Kühnel
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Federica Laguzzi
- Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Ilja M. Nolte
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Rainer Rauramaa
- Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine
- Muhammad Riaz
- College of Medicine, Biological Sciences and Psychology, Health Sciences, The Infant Mortality and Morbidity Studies (TIMMS)
- Antonietta Robino
- Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”
- Rico Rueedi
- Department of Computational Biology, University of Lausanne
- Heather M. Stringham
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Fumihiko Takeuchi
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Tibor V. Varga
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital
- Niek Verweij
- University of Groningen, University Medical Center Groningen, Department of Cardiology
- Erin B. Ware
- Survey Research Center, Institute for Social Research, University of Michigan
- Wanqing Wen
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine
- Xiaoyin Li
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Lisa R. Yanek
- Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine
- Najaf Amin
- Department of Epidemiology, Erasmus University Medical Center
- Donna K. Arnett
- Dean’s Office, University of Kentucky College of Public Health
- Eric Boerwinkle
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Marco Brumat
- Department of Medical Sciences, University of Trieste
- Brian Cade
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Mickaël Canouil
- CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille
- Yii-Der Ida Chen
- The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Maria Pina Concas
- Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”
- John Connell
- Ninewells Hospital & Medical School, University of Dundee
- Renée de Mutsert
- Clinical Epidemiology, Leiden University Medical Center
- H. Janaka de Silva
- Department of Medicine, Faculty of Medicine, University of Kelaniya
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Ayşe Demirkan
- Department of Epidemiology, Erasmus University Medical Center
- Jingzhong Ding
- Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine
- Charles B. Eaton
- Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University
- Jessica D. Faul
- Survey Research Center, Institute for Social Research, University of Michigan
- Yechiel Friedlander
- Braun School of Public Health, Hebrew University-Hadassah Medical Center
- Kelley P. Gabriel
- Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Austin
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center
- Franco Giulianini
- Preventive Medicine, Brigham and Women’s Hospital
- Chi Charles Gu
- Division of Biostatistics, Washington University School of Medicine
- Dongfeng Gu
- Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Jiang He
- Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Sami Heikkinen
- Institute of Biomedicine, School of Medicine, University of Eastern Finland
- Chew-Kiat Heng
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Steven C. Hunt
- Division of Epidemiology, Department of Internal Medicine, University of Utah
- M. Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center
- Jost B. Jonas
- Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg
- Woon-Puay Koh
- Saw Swee Hock School of Public Health, National University Health System and National University of Singapore
- Pirjo Komulainen
- Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine
- Jose E. Krieger
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Stephen B. Kritchevsky
- Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine
- Zoltán Kutalik
- Swiss Institute of Bioinformatics
- Johanna Kuusisto
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Carl D. Langefeld
- Department of Biostatistical Sciences, Wake Forest School of Medicine
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Karin Leander
- Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Rozenn N. Lemaitre
- Cardiovascular Health Research Unit, Medicine, University of Washington
- Cora E. Lewis
- Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, School of Medicine
- Jingjing Liang
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Lifelines Cohort Study
- Jianjun Liu
- Genome Institute of Singapore, Agency for Science Technology and Research
- Reedik Mägi
- Estonian Genome Center, University of Tartu
- Ani Manichaikul
- Center for Public Health Genomics, University of Virginia School of Medicine
- Thomas Meitinger
- Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Andres Metspalu
- Estonian Genome Center, University of Tartu
- Yuri Milaneschi
- Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center
- Karen L. Mohlke
- Department of Genetics, University of North Carolina
- Thomas H. Mosley
- Geriatrics, Medicine, University of Mississippi
- Alison D. Murray
- The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen
- Mike A. Nalls
- Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging
- Ei-Ei Khaing Nang
- Saw Swee Hock School of Public Health, National University Health System and National University of Singapore
- Christopher P. Nelson
- Department of Cardiovascular Sciences, University of Leicester
- Sotoodehnia Nona
- Cardiovascular Health Research Unit, Division of Cardiology, University of Washington
- Jill M. Norris
- Department of Epidemiology, University of Colorado Denver
- Chiamaka Vivian Nwuba
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Jeff O’Connell
- Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine
- Nicholette D. Palmer
- Department of Biochemistry, Wake Forest School of Medicine
- George J. Papanicolau
- Epidemiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
- Raha Pazoki
- Department of Epidemiology and Biostatistics, Imperial College London
- Nancy L. Pedersen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Ozren Polasek
- Department of Public Health, Department of Medicine, University of Split
- David J. Porteous
- Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh
- Alaitz Poveda
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Stephen S. Rich
- Center for Public Health Genomics, University of Virginia School of Medicine
- Neil Risch
- Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California
- Jennifer G. Robinson
- Department of Epidemiology and Medicine, University of Iowa
- Lynda M. Rose
- Preventive Medicine, Brigham and Women’s Hospital
- Igor Rudan
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Pamela J. Schreiner
- Division of Epidemiology & Community Health, School of Public Health, University of Minnesota
- Robert A. Scott
- MRC Epidemiology Unit, University of Cambridge
- Stephen S. Sidney
- Kaiser Permanente Washington, Health Research Institute
- Mario Sims
- Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Tamar Sofer
- Department of Medicine, Harvard Medical School
- John M. Starr
- Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh
- Barbara Sternfeld
- Kaiser Permanente Washington, Health Research Institute
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Hua Tang
- Department of Genetics, Stanford University
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Michael Y. Tsai
- Department of Laboratory Medicine and Pathology, University of Minnesota
- Jaakko Tuomilehto
- Public Health Solutions, National Institute for Health and Welfare
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus University Medical Center
- M. Yldau van der Ende
- University of Groningen, University Medical Center Groningen, Department of Cardiology
- Diana van Heemst
- Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center
- Trudy Voortman
- Department of Epidemiology, Erasmus University Medical Center
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Patrik Wennberg
- Department of Public Health & Clinical Medicine, Umeå University
- Gregory Wilson
- Jackson Heart Study, School of Public Health, Jackson State University
- Yong-Bing Xiang
- State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Jie Yao
- The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Caizheng Yu
- Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology
- Jian-Min Yuan
- Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- Alan B. Zonderman
- Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Diane M. Becker
- Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine
- Michael Boehnke
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Donald W. Bowden
- Department of Biochemistry, Wake Forest School of Medicine
- Ulf de Faire
- Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh
- Paul Elliott
- Department of Epidemiology and Biostatistics, Imperial College London
- Tõnu Esko
- Estonian Genome Center, University of Tartu
- Barry I. Freedman
- Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine
- Philippe Froguel
- CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille
- Paolo Gasparini
- Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Norihiro Kato
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
- Markku Laakso
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Timo A. Lakka
- Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Patrik K. E. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm
- Albertine J. Oldehinkel
- Department of Psychiatry, University of Groningen, University Medical Center Groningen
- Brenda W. J. H. Penninx
- Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, VU University Medical Center
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine
- Pim van der Harst
- University of Groningen, University Medical Center Groningen, Department of Cardiology
- Jana V. Van Vliet-Ostaptchouk
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Peter Vollenweider
- Internal Medicine, Department of Medicine, Lausanne University Hospital
- Lynne E. Wagenknecht
- Public Health Sciences, Wake Forest School of Medicine
- Ya X. Wang
- Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge
- David R. Weir
- Survey Research Center, Institute for Social Research, University of Michigan
- Tangchun Wu
- Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine
- Xiaofeng Zhu
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Michele K. Evans
- Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health
- Paul W. Franks
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital
- Vilmundur Gudnason
- Icelandic Heart Association
- Caroline Hayward
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Bernardo L. Horta
- Postgraduate Program in Epidemiology, Federal University of Pelotas
- Tanika N. Kelly
- Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Yongmei Liu
- Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences
- Kari E. North
- Epidemiology, University of North Carolina Gillings School of Global Public Health
- Alexandre C. Pereira
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Paul M. Ridker
- Preventive Medicine, Brigham and Women’s Hospital
- E. Shyong Tai
- Saw Swee Hock School of Public Health, National University Health System and National University of Singapore
- Rob M. van Dam
- Saw Swee Hock School of Public Health, National University Health System and National University of Singapore
- Ervin R. Fox
- Cardiology, Medicine, University of Mississippi Medical Center
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Ching-Ti Liu
- Biostatistics, Boston University School of Public Health
- Dennis O. Mook-Kanamori
- Clinical Epidemiology, Leiden University Medical Center
- Michael A. Province
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Susan Redline
- Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus University Medical Center
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Division of Genomic Outcomes, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Charles B. Kooperberg
- Fred Hutchinson Cancer Research Center, University of Washington School of Public Health
- W. James Gauderman
- Biostatistics, Preventive Medicine, University of Southern California
- Bruce M. Psaty
- Kaiser Permanente Washington, Health Research Institute
- Kenneth Rice
- Department of Biostatistics, University of Washington
- Patricia B. Munroe
- Clinical Pharmacology, William Harvey Research Instititute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Myriam Fornage
- Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- L. Adrienne Cupples
- Biostatistics, Boston University School of Public Health
- Charles N. Rotimi
- Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston
- Dabeeru C. Rao
- Division of Biostatistics, Washington University School of Medicine
- Ruth J. F. Loos
- Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine
- DOI
- https://doi.org/10.1038/s41467-018-08008-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.
