PLoS ONE (Jan 2014)

Impact of vitamin D supplementation during lactation on vitamin D status and body composition of mother-infant pairs: a MAVID randomized controlled trial.

  • Justyna Czech-Kowalska,
  • Julita Latka-Grot,
  • Dorota Bulsiewicz,
  • Maciej Jaworski,
  • Pawel Pludowski,
  • Grazyna Wygledowska,
  • Bogdan Chazan,
  • Beata Pawlus,
  • Anna Zochowska,
  • Maria K Borszewska-Kornacka,
  • Elzbieta Karczmarewicz,
  • Edyta Czekuc-Kryskiewicz,
  • Anna Dobrzanska

DOI
https://doi.org/10.1371/journal.pone.0107708
Journal volume & issue
Vol. 9, no. 9
p. e107708

Abstract

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The optimal vitamin D intake for nursing women is controversial. Deterioration, at least in bone mass, is reported during lactation. This study evaluated whether vitamin D supplementation during lactation enhances the maternal and infant's vitamin D status, bone mass and body composition.After term delivery, 174 healthy mothers were randomized to receive 1200 IU/d (800 IU/d+400 IU/d from multivitamins) or 400 IU/d (placebo+400 IU/d from multivitamins) of cholecalciferol for 6 months while breastfeeding. All infants received 400 IU/d of cholecalciferol. Serum 25-hydroxyvitamin D [25(OH)D], iPTH, calcium, urinary calcium, and densitometry were performed in mother-offspring pairs after delivery, and at 3 and 6 months later.A total of 137 (79%) (n = 70; 1200 IU/d, n = 67; 400 IU/d) completed the study. 25(OH)D was similar in both groups at baseline (13.7 ng/ml vs. 16.1 ng/ml; P = 0.09) and at 3 months (25.7 ng/ml vs. 24.5 ng/ml; P = 0.09), but appeared higher in the 1200 IU/d group at 6 months of supplementation (25.6 ng/ml vs. 23.1 ng/ml; P = 0.009). The prevalence of 25(OH)D 20 ng/ml in nursing women, while 1200 IU/d appeared more effective, but had no effect on breastfed offspring vitamin D status, or changes in the bone mass and the body composition observed in both during breastfeeding.ClinicalTrials.gov NCT01506557.