Вопросы современной педиатрии (Aug 2016)

Experience in Rituximab Administration in Children with Systemic Lupus Erythematosus: a Retrospective Study of the Case Series

  • Mikhail M. Kostik,
  • Ekaterina M. Kuchinskaya,
  • Farida N. Abduragimova,
  • Olga P. Gurina,
  • Olga V. Kalashnikova,
  • Vyacheslav G. Chasnyk

DOI
https://doi.org/10.15690/vsp.v15i3.1567
Journal volume & issue
Vol. 15, no. 3
pp. 295 – 300

Abstract

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Systemic lupus erythematosus (SLE) in children has unpredictable and severe course. There is currently no standard therapy for the treatment of the disease. The article presents the results of a retrospective study of rituximab efficiency in 16 children with SLE aged 5 to 16 years who were hospitalized. Rituximab was administered to patients with a severe life-threatening course of the disease when the hormone-cytostatic therapy was ineffective or the reduction of the daily dose of corticosteroids was impossible. The administered drug dose was 375 mg/m2 weekly during 4 weeks. The therapy with rituximab is noted with a clinically significant decrease in the values of laboratory parameters of the disease activity, SLEDAI, ECLAM disease activity indices, SLICC/ACR impairment index, as well as a daily dose of corticosteroids. 1 case of pneumonia and 2 cases of death associated with generalized mycotic infection are reported.

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