GENETICAL ASPECTS OF SURGICAL TREATMENT IN PATIENTS WITH HEREDITARY BREAST CANCER

Abstract

Numerous available results of investigations confirmed the important role of prophylactic bilateral laparoscopic salpingo-oophorectomy and contralateral prophylactic subcutaneous mastectomy in decrease of risks of malignant tumors of the reproductive system when mutation carriers of BRCA1 and BRCA2 presented. Recommendations to surgical treatment of hereditary breast cancer are considered as a very difficult task which should be based on risks and advantages of prophylactic surgical interventions. Presented surgical operations could be applied in mutation carriers of reparation DNA genes and patients with hereditary breast cancer aimed to improve the indices of general survival rate and quality of life.

Keywords

• наследственный рак молочной железы
• профилактическая контралатеральная мастэктомия
• профилактическая билатеральная сальпингоофорэктомия
• hereditary breast cancer
• prophylactic contralateral mastectomy
• prophylactic bilateral salpingo-oophorectomy