Case Reports in Oncology (Jan 2017)

Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

  • Yota Sato,
  • Taku Fujimura,
  • Yumi Kambayashi,
  • Akira Tsukada,
  • Takanori Hidaka,
  • Kayo Tanita,
  • Takahiro Haga,
  • Akira Hashimoto,
  • Setsuya Aiba

DOI
https://doi.org/10.1159/000456001
Journal volume & issue
Vol. 10, no. 1
pp. 106 – 111

Abstract

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Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.

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