Nature Communications (Jul 2019)
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
- Krist Helen Antunes,
- José Luís Fachi,
- Rosemeire de Paula,
- Emanuelle Fraga da Silva,
- Laís Passariello Pral,
- Adara Áurea dos Santos,
- Greicy Brisa Malaquias Dias,
- José Eduardo Vargas,
- Renato Puga,
- Fabiana Quoos Mayer,
- Fábio Maito,
- Carlos R. Zárate-Bladés,
- Nadim J. Ajami,
- Marcella Ramos Sant’Ana,
- Thamiris Candreva,
- Hosana Gomes Rodrigues,
- Marcio Schmiele,
- Maria Teresa Pedrosa Silva Clerici,
- José Luiz Proença-Modena,
- Angélica Thomas Vieira,
- Charles R. Mackay,
- Daniel Mansur,
- Mauricio T. Caballero,
- Jacqui Marzec,
- Jianying Li,
- Xuting Wang,
- Douglas Bell,
- Fernando P. Polack,
- Steven R. Kleeberger,
- Renato T. Stein,
- Marco Aurélio Ramirez Vinolo,
- Ana Paula Duarte de Souza
Affiliations
- Krist Helen Antunes
- Laboratory of Clinical and Experimental Immunology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul
- José Luís Fachi
- Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas
- Rosemeire de Paula
- Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas
- Emanuelle Fraga da Silva
- Laboratory of Clinical and Experimental Immunology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul
- Laís Passariello Pral
- Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas
- Adara Áurea dos Santos
- Laboratory of Imunobiology, Departament of Microbiology, Immunology and Parasitology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina
- Greicy Brisa Malaquias Dias
- Laboratory of Imunobiology, Departament of Microbiology, Immunology and Parasitology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina
- José Eduardo Vargas
- Biological Science Institute (ICB), Passo Fundo University
- Renato Puga
- Clinical Research Center, Hospital Israelita Albert Einstein HIAE
- Fabiana Quoos Mayer
- Molecular Biology Laboratory, Veterinary Research Institute Desidério Finamor, Agricultural Diagnosis and Research Department, Secretariat of Agriculture, Livestock and Irrigation
- Fábio Maito
- Laboratory of Pathology, Healthy Science School, Pontifical Catholic University of Rio Grande do Sul
- Carlos R. Zárate-Bladés
- Laboratory of Iimmunoregulation, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, UFSC
- Nadim J. Ajami
- Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Marcella Ramos Sant’Ana
- Laboratory of Nutritional Genomics, School of Applied Sciences, University of Campinas
- Thamiris Candreva
- Laboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas
- Hosana Gomes Rodrigues
- Laboratory of Nutrients and Tissue Repair, School of Applied Sciences, University of Campinas
- Marcio Schmiele
- Institute of Science and Technology, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM)
- Maria Teresa Pedrosa Silva Clerici
- Department of Food Technology, School of Food Engineering, University of Campinas (UNICAMP) – Cidade Universitária Zeferino Vaz, Monteiro Lobato, 80
- José Luiz Proença-Modena
- Emerging viruses study Laboratory, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas
- Angélica Thomas Vieira
- Department of Biochemistry and Immunology, Federal University of Minas Gerais
- Charles R. Mackay
- Biodiscovery Research Institute, Monash University
- Daniel Mansur
- Laboratory of Imunobiology, Departament of Microbiology, Immunology and Parasitology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina
- Mauricio T. Caballero
- Fundación INFANT
- Jacqui Marzec
- National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
- Jianying Li
- National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
- Xuting Wang
- National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
- Douglas Bell
- National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
- Fernando P. Polack
- Fundación INFANT
- Steven R. Kleeberger
- National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle
- Renato T. Stein
- Infant Center, School of Medicine, Department of Pediatrics, São Lucas Hospital PUCRS
- Marco Aurélio Ramirez Vinolo
- Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology - Institute of Biology, University of Campinas
- Ana Paula Duarte de Souza
- Laboratory of Clinical and Experimental Immunology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul
- DOI
- https://doi.org/10.1038/s41467-019-11152-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in the lungs.
