Nature Communications (Nov 2018)
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
- Ana Angulo-Urarte,
- Pedro Casado,
- Sandra D. Castillo,
- Piotr Kobialka,
- Maria Paraskevi Kotini,
- Ana M. Figueiredo,
- Pau Castel,
- Vinothini Rajeeve,
- Maria Milà-Guasch,
- Jaime Millan,
- Cora Wiesner,
- Helena Serra,
- Laia Muixi,
- Oriol Casanovas,
- Francesc Viñals,
- Markus Affolter,
- Holger Gerhardt,
- Stephan Huveneers,
- Heinz-Georg Belting,
- Pedro R. Cutillas,
- Mariona Graupera
Affiliations
- Ana Angulo-Urarte
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Pedro Casado
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London
- Sandra D. Castillo
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Piotr Kobialka
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Maria Paraskevi Kotini
- Biozentrum der Universität Basel
- Ana M. Figueiredo
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Pau Castel
- Helen Diller Family Comprehensive Cancer Center, University of California-San Francisco
- Vinothini Rajeeve
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London
- Maria Milà-Guasch
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Jaime Millan
- Centro de Biología Molecular Severo Ochoa, CSIC-UAM
- Cora Wiesner
- Biozentrum der Universität Basel
- Helena Serra
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Laia Muixi
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- Oriol Casanovas
- Translation Research Laboratory, ProCURE, Oncobell Program, IDIBELL
- Francesc Viñals
- Translation Research Laboratory, ProCURE, Oncobell Program, IDIBELL
- Markus Affolter
- Biozentrum der Universität Basel
- Holger Gerhardt
- Max-Delbrueck Center for Molecular Medicine (MDC)
- Stephan Huveneers
- Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences
- Heinz-Georg Belting
- Biozentrum der Universität Basel
- Pedro R. Cutillas
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London
- Mariona Graupera
- Vascular Signalling Laboratory, ProCURE, Oncobell Program, Institut d´Investigació Biomèdica de Bellvitge (IDIBELL)
- DOI
- https://doi.org/10.1038/s41467-018-07172-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.
