Congenital pathological tortuosity of the internal carotid artery: population screening and genetic aspects

Abstract

In the present work results of screening of different variants ofpathological tortuosity of internal carotids in a general childrenpopulation and in a selected group of children suffering frommigraine and migraine-like headache are presented. High prevalence of pathological tortuosity of internal carotids, includinghemodynamically significant variants of tortuosity in both investigated groups, is noted. Data of clinical, morphological,genealogical and genetic investigations confirmed hereditarydeterminancy of pathological carotid tortuosity and its interrelation with hereditary syndromal pathology of connective tissue.

Keywords

• pathological tortuosity of the internal carotid artery
• screening
• duplex scanning
• dysplasia of connective tissue
• ehlers–danlos syndrome
• segregation analysis