Cells (Nov 2024)

Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling

  • Lei Wang,
  • Rui Zhu,
  • Zehua Wen,
  • Hua-Jun Shawn Fan,
  • Teresa Norwood-Jackson,
  • Danielle Jathan,
  • Ho-Jin Lee

DOI
https://doi.org/10.3390/cells13221870
Journal volume & issue
Vol. 13, no. 22
p. 1870

Abstract

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Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL’s role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions remain unresolved. Herein, we present the recent advances and perspectives on how DVL regulates signaling. The experimentally determined conserved domain structures of DVL in conjunction with AlphaFold-predicted structures are used to understand the DVL’s role in Wnt signaling regulation. We also summarize the role of DVL in various diseases and provide insights into further directions for research on the DVL-mediated signaling mechanisms. These findings underscore the importance of DVL as a pharmaceutical target or biological marker in diseases, offering exciting potential for future biomedical applications.

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