Communications Biology (Oct 2022)
Paraquat is an agonist of STIM1 and increases intracellular calcium levels
- Wenyu Yang,
- Rui Tian,
- Yong Zhu,
- Peijie Huang,
- Xinrun Ma,
- Xiaoxiao Meng,
- Wentao Dai,
- Yiming Tao,
- Daonan Chen,
- Jiaxiang Zhang,
- Jian Lu,
- Hui Xie,
- Xiangdong Jian,
- Zhengfeng Yang,
- Ruilan Wang
Affiliations
- Wenyu Yang
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Rui Tian
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Yong Zhu
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Peijie Huang
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Xinrun Ma
- Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Xiaoxiao Meng
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Wentao Dai
- Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology
- Yiming Tao
- Department of Poisoning and Occupational Diseases, Emergency, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Daonan Chen
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Jiaxiang Zhang
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Jian Lu
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Hui Xie
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Xiangdong Jian
- Department of Poisoning and Occupational Diseases, Emergency, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Zhengfeng Yang
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- Ruilan Wang
- Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-04130-0
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 11
Abstract
The herbicide paraquat is an agonist of Stromal Interaction Molecule 1 (STIM1), leading to extracellular calcium entry observed in epithelial-mesenchymal transition in alveolar cells during pulmonary fibrosis.
