Decreased MiR-30a promotes TGF-β1-mediated arachnoid fibrosis in post-hemorrhagic hydrocephalus

Zhan Chaohong; Xiao Gelei; Zhang Xiangyang; Chen Xiaoyu; Zhang Zhiping; Liu Jingping

doi:10.1515/tnsci-2020-0010

Translational Neuroscience (May 2020)

Decreased MiR-30a promotes TGF-β1-mediated arachnoid fibrosis in post-hemorrhagic hydrocephalus

Zhan Chaohong,
Xiao Gelei,
Zhang Xiangyang,
Chen Xiaoyu,
Zhang Zhiping,
Liu Jingping

Affiliations

Zhan Chaohong: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China
Xiao Gelei: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China
Zhang Xiangyang: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China
Chen Xiaoyu: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China
Zhang Zhiping: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China
Liu Jingping: Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P. R. China

DOI: https://doi.org/10.1515/tnsci-2020-0010
Journal volume & issue: Vol. 11, no. 1
pp. 60 – 74

Abstract

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Fibrosis in the ventricular system is closely associated with post-hemorrhagic hydrocephalus (PHH). It is characterized by an expansion of the cerebral ventricles due to CSF accumulation following intraventricular hemorrhage (IVH). The activation of transforming growth factor-β1 (TGF-β1) may be involved in thrombin-induced arachnoid fibrosis.

Published in Translational Neuroscience

ISSN: 2081-6936 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.degruyter.com/view/j/tnsci

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