STUDY OF TENASCIN-C (TN-C) PROTEIN ROLE IN ORAL MALIGNANCY PROGRESSIVITY PROCESS BY MOLECULAR BIOLOGICAL APPROACH

Abstract

The progressiveness of malignant tumors influenced by various complex factors. One of the important factors is Tenascin-C (Tn-C) protein, which can interact with fibrinectin as an anti adhesive or anti modulation protein. Tenascin-C is an extra cellular matrix glycoprotein (EMG), which can be found in the oral tissue also as an up regulator. They can be associated with EMG, and strongly influenced promotion of the stromal cell as cell growth, migration, differentiation, angiogenesis, and apoptosis in cancer. Alternative splicing of fibronectin-like type III (FN III) repeats of Tn-C generates a number of splice variants, and influences tumor progressiveness. The conclusion of Tn-C role in tumor progressiveness depends on the molecular weight and alternative splicing of FN III.