CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF BETALEUKIN IN PATIENTS WITH INFLUENZA AND FLU-LIKE DISEASES COMPLICATED BY PNEUMONIA

Abstract

This investigation was aimed for studying efficacy of Betaleukin in combined therapy of influenza and flu-like respiratory diseases complicated by pneumonia, and development of inclusion criteria. Treatment with Betaleukin was significantly associated with shorter duration of catarrhal syndrome and decreased resolution terms of lung infiltrates. Usage of Betaleukin was shown to influence the levels of pro- and anti-inflammatory cytokines and interferons. Betaleukin is effective in patients under 50 years old, independent on initial volume of lung infiltrates. Full resolution of pneumonia treated with Betaleukin was observed in patients with initial IL-1β concentrations under 80 pg/ml, or 80-120 pg/ml, and IL-1rа concentrations of 500-1000 pg/ml in blood serum.

Keywords

• influenza
• pneumonia
• clinical pattern
• cytokines
• betaleukin
• therapeutic efficacy