International Journal of Molecular Sciences (May 2019)
Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia
- Minerva Mata-Rocha,
- Angelica Rangel-López,
- Elva Jiménez-Hernández,
- Blanca Angélica Morales-Castillo,
- Carolina González-Torres,
- Javier Gaytan-Cervantes,
- Enrique Álvarez-Olmos,
- Juan Carlos Núñez-Enríquez,
- Arturo Fajardo-Gutiérrez,
- Jorge Alfonso Martín-Trejo,
- Karina Anastacia Solís-Labastida,
- Aurora Medina-Sansón,
- Janet Flores-Lujano,
- Omar Alejandro Sepúlveda-Robles,
- José Gabriel Peñaloza-González,
- Laura Eugenia Espinoza-Hernández,
- Nora Nancy Núñez-Villegas,
- Rosa Martha Espinosa-Elizondo,
- Beatriz Cortés-Herrera,
- José Refugio Torres-Nava,
- Luz Victoria Flores-Villegas,
- Laura Elizabeth Merino-Pasaye,
- Vilma Carolina Bekker-Méndez,
- Martha Margarita Velázquez-Aviña,
- María Luisa Pérez-Saldívar,
- Benito Alejandro Bautista-Martínez,
- Raquel Amador-Sánchez,
- Ana Itamar González-Avila,
- Silvia Jiménez-Morales,
- David Aldebarán Duarte-Rodríguez,
- Jessica Denisse Santillán-Juárez,
- Alejandra Jimena García-Velázquez,
- Haydeé Rosas-Vargas,
- Juan Manuel Mejía-Aranguré
Affiliations
- Minerva Mata-Rocha
- CONACyT-Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Angelica Rangel-López
- Coordinacion de Investigacion en Salud, Unidad Habilitada de Apoyo al Predictamen, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Elva Jiménez-Hernández
- Servicio de Hematologia Pediatrica, Hospital General “Gaudencio González Garza”, Centro Medico Nacional (CMN) “La Raza”, IMSS, 02990 Mexico City, Mexico
- Blanca Angélica Morales-Castillo
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Carolina González-Torres
- Laboratorio de Secuenciación, Division de Desarrollo de la Investigacion, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Javier Gaytan-Cervantes
- Laboratorio de Secuenciación, Division de Desarrollo de la Investigacion, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Enrique Álvarez-Olmos
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Juan Carlos Núñez-Enríquez
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Arturo Fajardo-Gutiérrez
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Jorge Alfonso Martín-Trejo
- Servicio de Hematologia, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Karina Anastacia Solís-Labastida
- Servicio de Hematologia, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Aurora Medina-Sansón
- Servicio de Oncología, Hospital Infantil de Mexico Federico Gómez, Secretaria de Salud, 06720 Mexico City, Mexico
- Janet Flores-Lujano
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Omar Alejandro Sepúlveda-Robles
- CONACyT-Unidad de Investigacion Medica en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Siglo XXI, IMSS, 06720 Mexico City, Mexico
- José Gabriel Peñaloza-González
- Servicio de Onco-Pediatria, Hospital Juarez de Mexico, Secretaria de Salud, 07760 Mexico City, Mexico
- Laura Eugenia Espinoza-Hernández
- Servicio de Hematologia Pediatrica, Hospital General “Gaudencio González Garza”, Centro Medico Nacional (CMN) “La Raza”, IMSS, 02990 Mexico City, Mexico
- Nora Nancy Núñez-Villegas
- Servicio de Hematologia Pediatrica, Hospital General “Gaudencio González Garza”, Centro Medico Nacional (CMN) “La Raza”, IMSS, 02990 Mexico City, Mexico
- Rosa Martha Espinosa-Elizondo
- Servicio de Hematologia Pediatrica, Hospital General de Mexico, Secretaria de Salud, 06726 Mexico City, Mexico
- Beatriz Cortés-Herrera
- Servicio de Hematologia Pediatrica, Hospital General de Mexico, Secretaria de Salud, 06726 Mexico City, Mexico
- José Refugio Torres-Nava
- Servicio de Oncología, Hospital Pediatrico de Moctezuma, Secretaria de Salud de la Ciudad de Mexico, Ciudad de Mexico, 15530 Mexico City, Mexico
- Luz Victoria Flores-Villegas
- Servicio de Hematologia Pediatrica, Centro Medico Nacional “20 de Noviembre”, ISSSTE, 03229 Mexico City, Mexico
- Laura Elizabeth Merino-Pasaye
- Servicio de Hematologia Pediatrica, Centro Medico Nacional “20 de Noviembre”, ISSSTE, 03229 Mexico City, Mexico
- Vilma Carolina Bekker-Méndez
- Unidad de Investigacion Medico en Inmunologia e Infectologia, Hospital de Infectologia “Dr. Daniel Méndez Hernández”, “La Raza”, IMSS, 02990 Mexico City, Mexico
- Martha Margarita Velázquez-Aviña
- Servicio de Onco-Pediatria, Hospital Juarez de Mexico, Secretaria de Salud, 07760 Mexico City, Mexico
- María Luisa Pérez-Saldívar
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Benito Alejandro Bautista-Martínez
- Servicio de Hematologia, UMAE Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Raquel Amador-Sánchez
- Servicio de Hematologia Pediatrica, Hospital General Regional “Carlos McGregor Sanchez Navarro”, IMSS, 03100 Mexico City, Mexico
- Ana Itamar González-Avila
- Servicio de Hematologia Pediatrica, Hospital General Regional “Carlos McGregor Sanchez Navarro”, IMSS, 03100 Mexico City, Mexico
- Silvia Jiménez-Morales
- Laboratorio de Genomica del Cancer del Instituto Nacional de Medicina Genomica (INMEGEN), 14610 Mexico City, Mexico
- David Aldebarán Duarte-Rodríguez
- Unidad de Investigacion Medico en Epidemiologia Clinica, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Jessica Denisse Santillán-Juárez
- Servicio de Hemato-Oncologia Pediatrica, Hospital Regional 1° de Octubre, ISSSTE, 07300 Mexico City, Mexico
- Alejandra Jimena García-Velázquez
- Servicio de Hemato-Oncologia Pediatrica, Hospital Regional 1° de Octubre, ISSSTE, 07300 Mexico City, Mexico
- Haydeé Rosas-Vargas
- Unidad de Investigacion Medica en Genética Humana, Hospital de Pediatria, Centro Medico Nacional Siglo XXI, IMSS, 06720 Mexico City, Mexico
- Juan Manuel Mejía-Aranguré
- Coordinación de Investigacion en Salud, IMSS, Torre Academia Nacional de Medicina, 06720 Mexico City, Mexico
- DOI
- https://doi.org/10.3390/ijms20102394
- Journal volume & issue
-
Vol. 20,
no. 10
p. 2394
Abstract
Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.
Keywords
- leukemogenesis
- chromosomal translocation
- fusion gene
- RNA sequencing
- risk stratification
- genetic variations