STUDYING ASSOCIATIONS OF TWO COMMON S27P AND -15С→T POLYMORPHISMS OF THE INTERLEUKIN-3 GENE WITH DEVELOPMENT OF ALLERGIC AND NON-ALLERGIC BRONCHIAL ASTHMA IN RUSSIANS FROM THE CENTRAL-CHERNOZEM REGION

Medicinskaâ Immunologiâ. 2014;8(5-6):731-736 DOI 10.15789/1563-0625-2006-5-6-731-736

 

Journal Homepage

Journal Title: Medicinskaâ Immunologiâ

ISSN: 1563-0625 (Print); 2313-741X (Online)

Publisher: SPb RAACI

Society/Institution: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Country of publisher: Russian Federation

Language of fulltext: Russian

Full-text formats available: PDF

 

AUTHORS


A. V. Polonikov (Курский государственный медицинский университет)

V. P. Ivanov (Курский государственный медицинский университет)

D. A. Belugin (Курский государственный университет)

I. V. Khoroshaya (Курский государственный медицинский университет)

M. A. Solodilova (Курский государственный медицинский университет)

V. I. Panfilov (Курская областная клиническая больница, г. Курск)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 12 weeks

 

Abstract | Full Text

Abstract. The purpose of our study was to investigate whether S27P and -15С→T single nucleotide polymorphisms of the IL3 gene are associated with susceptibility to bronchial asthma (BA) in Russians living in the Central-Chernozem region of Russia. DNA samples obtained from 216 unrelated patients with BA and 214 healthy controls were typed for S27P and -15С→T polymorphisms in the IL3 gene by PCR-RFLP methods. Gender-based differences in the distribution of IL3 genotypes have been revealed between controls and patients with asthma. Both S27P and -15С→T polymorphisms were found to associate with common susceptibility to BA predominantly in females (p=0,05). Studied genetic variants of IL3 gene were in strong linkage disequilibrium with each other (p<0,0001). Further studies are required to investigate phenotypic expression of S27P and -15С→T polymorphisms of IL3 gene and to clarify their roles in the pathogenesis of bronchial asthma.