BMJ Global Health (Nov 2020)
Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review
- Sanjeev Krishna,
- Andrew Shennan,
- Helena Boene,
- Marianne Vidler,
- Laura A Magee,
- Esperanca Sevene,
- Peter von Dadelszen,
- Eusébio Macete,
- Anifa Vala,
- Salésio Macuacua,
- Sónia Maculuve,
- Jeffrey Bone,
- Beth A Payne,
- Jane Sandall,
- Veronique Filippi,
- Lucilla Poston,
- Kate Bramham,
- Lucy Chappell,
- Melisa Martinez-Alvarez,
- Geoffrey Omuse,
- Guy Whitley,
- Hannah Blencowe,
- Sean Beevers,
- Rachel Craik,
- Marleen Temmerman,
- Jeffrey N Bone,
- Kelly Pickerill,
- Mai-Lei Woo Kinshella,
- William Stones,
- Angela Koech Etyang,
- Anna Roca,
- Donna Russell,
- Rachel M Tribe,
- Umberto D’Alessandro,
- Hawanatu Jah,
- Ofordile Oguchukwu,
- Andrew Prentice,
- Brahima Diallo,
- Adbul Sesey,
- Kodou Lette,
- Alpha Bah,
- Chilel Sanyang,
- Angela Koech Etyang,
- Peris Musitia,
- Mary Amondi,
- David Chege,
- Patricia Okiro,
- Sikolia Wanyonyi,
- Paulo Chin,
- Corssino Tchavana,
- Lazaro Quimice,
- Carla Carillho,
- Peter von Dadelszen,
- Meriel Flint-O’Kane,
- Amber Strang,
- Marina Daniele,
- Tatenda Makanga,
- Liberty Makacha,
- Yolisa Dube,
- Newton Nyapwere,
- Rachel Tribe,
- Sophie Moore,
- Tatiana Salisbury,
- Ben Barratt,
- Aris Papageorgiou,
- Alison Noble,
- Joy Lawn,
- Matt Silver,
- Matthew Chico,
- Judith Cartwright,
- Jing (Larry) Li,
- Mai-Lei (Maggie) Woo Kinshella,
- Domena Tu,
- Warancha Tumtaweetikul,
- Marie-Laure Volvert
Affiliations
- Sanjeev Krishna
- Andrew Shennan
- Department of Women and Children’s Health, School of Life Course Sciences, King`s College London, London, UK
- Helena Boene
- Centro de Investigacao em Saude de Manhica, Manhica, Mozambique
- Marianne Vidler
- Department of Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada
- Laura A Magee
- Department of Obstetrics and Gynaecology, The University of British Columbia, Vancouver, British Columbia, Canada
- Esperanca Sevene
- Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique
- Peter von Dadelszen
- Department of Women and Children`s Health, King`s College London, London, UK
- Eusébio Macete
- Centro de Investigação em Saúde de Manhiça, Manhica, Mozambique
- Anifa Vala
- Centro de Investigação em Saúde de Manhiça, Manhica, Mozambique
- Salésio Macuacua
- Centro de Investigação em Saúde da Manhiça (CISM), Maputo, Mozambique
- Sónia Maculuve
- Jeffrey Bone
- Beth A Payne
- Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada
- Jane Sandall
- Division of Women`s Health, Women`s Health Academic Centre, King`s College, London, St. Thomas` Hospital, London, UK
- Veronique Filippi
- London School of Hygiene & Tropical Medicine, London, UK
- Lucilla Poston
- Department of Women and Children’s Health, Faculty of Life Sciences and Medicine, King`s College London, London, UK
- Kate Bramham
- consultant nephrologist
- Lucy Chappell
- Methodologies Department, King’s College London, London, UK
- Melisa Martinez-Alvarez
- Department of Global Health and Development, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Dakar, Senegal
- Geoffrey Omuse
- Department of Pathology, Aga Khan University, Nairobi, Kenya
- Guy Whitley
- Hannah Blencowe
- Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK
- Sean Beevers
- MRC Centre for Environment and Health, Imperial College London, London, UK
- Rachel Craik
- Department of Women and Children’s Health, King`s College London, School of Life Course Sciences, Faculty of Life Sciences and Medicine, London, UK
- Marleen Temmerman
- Centre of Excellence in Women and Child Health, Aga Khan University, Nairobi, Kenya
- Jeffrey N Bone
- 3 BC Children`s Hospital Research Institute, Vancouver, British Columbia, Canada
- Kelly Pickerill
- Department of Obstetrics and Gynaecology, The University of British Columbia, Faculty of Medicine, Vancouver, British Columbia, Canada
- Mai-Lei Woo Kinshella
- Department of Obstetrics and Gynaecology, The University of British Columbia, Faculty of Medicine, Vancouver, British Columbia, Canada
- William Stones
- Department of Obstetrics and Gynaecology, University of Malawi, College of Medicine, Blantyre, Malawi
- Angela Koech Etyang
- Centre of Excellence in Women and Child Health, Aga Khan University, Nairobi, Kenya
- Anna Roca
- Disease control and Elimination Theme, MRC Unit The Gambia at LSHTM, Banjul, The Gambia
- Donna Russell
- Renton, Washington, USA
- Rachel M Tribe
- Department of Women and Children’s Health, King`s College London, School of Life Course Sciences, Faculty of Life Sciences and Medicine, London, UK
- Umberto D’Alessandro
- Disease Elimination and Control, Medical Research Council Unit, Fajara, Gambia
- Hawanatu Jah
- Disease Control and Elimination, Medical Research Council Unit The Gambia, at London School of Hygiene and Tropical Medicine, Banjul, Gambia
- Ofordile Oguchukwu
- Andrew Prentice
- St Mark’s Bowel Cancer Screening Centre, London North West Healthcare NHS Trust, Harrow, UK
- Brahima Diallo
- Adbul Sesey
- Kodou Lette
- Alpha Bah
- Chilel Sanyang
- Angela Koech Etyang
- Peris Musitia
- Mary Amondi
- David Chege
- Patricia Okiro
- Sikolia Wanyonyi
- Paulo Chin
- Corssino Tchavana
- Lazaro Quimice
- Carla Carillho
- Peter von Dadelszen
- Meriel Flint-O’Kane
- Amber Strang
- Marina Daniele
- 4 Women and Children’s Health, King’s College London, London, UK
- Tatenda Makanga
- Liberty Makacha
- Yolisa Dube
- Newton Nyapwere
- Rachel Tribe
- Department of Women and Children’s Health, School of Life Course & Population Sciences, King`s College London, London, UK
- Sophie Moore
- Department of Women and Children`s Health, King`s College London, London, UK
- Tatiana Salisbury
- Ben Barratt
- Aris Papageorgiou
- Alison Noble
- Joy Lawn
- 2London School of Hygiene and Tropical Medicine
- Matt Silver
- Matthew Chico
- Judith Cartwright
- Jing (Larry) Li
- Mai-Lei (Maggie) Woo Kinshella
- Domena Tu
- Warancha Tumtaweetikul
- Marie-Laure Volvert
- DOI
- https://doi.org/10.1136/bmjgh-2020-003716
- Journal volume & issue
-
Vol. 5,
no. 11
Abstract
Background Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography, and high-income country data may not generalise to low-resource settings. We conducted a systematic review to identify prospective pregnancy cohorts in sub-Saharan Africa (SSA) that include biobanked samples with potential to enhance discovery science opportunity.Methods Inclusion criteria were prospective data collection during pregnancy, with associated biobanking in SSA. Data sources included: scientific databases (with comprehensive search terms), grey literature, hand searching applicable reference lists and expert input. Results were screened in a three-stage process based on title, abstract and full text by two independent reviewers. The review is registered on PROSPERO (CRD42019147483).Results Fourteen SSA studies met the inclusion criteria from database searches (n=8), reference list searches (n=2) and expert input (n=4). Three studies have ongoing data collection. The most represented countries were South Africa and Mozambique (Southern Africa) (n=3), Benin (Western Africa) (n=4) and Tanzania (Eastern Africa) (n=4); including an estimated 31 763 women. Samples commonly collected were blood, cord blood and placenta. Seven studies collected neonatal samples. Common clinical outcomes included maternal and perinatal mortality, malaria and preterm birth.Conclusions Increasingly numerous pregnancy cohorts in SSA that include biobanking are generating a uniquely valuable resource for collaborative discovery science, and improved understanding of the high regional risks of maternal, fetal and neonatal morbidity and mortality. Future studies should align protocols and consider their added value and distinct contributions.
