Nature Communications (Feb 2018)
Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
- Xunmei Yuan,
- Kazutaka Tsujimoto,
- Koshi Hashimoto,
- Kenichi Kawahori,
- Nozomi Hanzawa,
- Miho Hamaguchi,
- Takami Seki,
- Makiko Nawa,
- Tatsuya Ehara,
- Yohei Kitamura,
- Izuho Hatada,
- Morichika Konishi,
- Nobuyuki Itoh,
- Yoshimi Nakagawa,
- Hitoshi Shimano,
- Takako Takai-Igarashi,
- Yasutomi Kamei,
- Yoshihiro Ogawa
Affiliations
- Xunmei Yuan
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Kazutaka Tsujimoto
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Koshi Hashimoto
- Department of Preemptive Medicine and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Kenichi Kawahori
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Nozomi Hanzawa
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Miho Hamaguchi
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Takami Seki
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Makiko Nawa
- Laboratory of Cytometry and Proteome Research, Nanken-Kyoten and Research Core Center, Tokyo Medical and Dental University
- Tatsuya Ehara
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- Yohei Kitamura
- Wellness and Nutrition Science Institute, Morinaga Milk Industry Co., Ltd
- Izuho Hatada
- Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University
- Morichika Konishi
- Department of Microbial Chemistry, Kobe Pharmaceutical University
- Nobuyuki Itoh
- Medical Innovation Center, Kyoto University Graduate School of Medicine
- Yoshimi Nakagawa
- Department of Internal Medicine (Metabolism and Endocrinology), Faculty of Medicine, University of Tsukuba
- Hitoshi Shimano
- Department of Internal Medicine (Metabolism and Endocrinology), Faculty of Medicine, University of Tsukuba
- Takako Takai-Igarashi
- Tohoku Medical Megabank Organization
- Yasutomi Kamei
- Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
- Yoshihiro Ogawa
- Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University
- DOI
- https://doi.org/10.1038/s41467-018-03038-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adulthood.
