Low Bone Mineral Density in Hemophiliacs

Jennifer Gebetsberger; Michael Schirmer; Walter J. Wurzer; Werner Streif

doi:10.3389/fmed.2022.794456

Frontiers in Medicine (Feb 2022)

Low Bone Mineral Density in Hemophiliacs

Jennifer Gebetsberger,
Michael Schirmer,
Walter J. Wurzer,
Werner Streif

Affiliations

Jennifer Gebetsberger: Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria
Michael Schirmer: Department of Internal Medicine, Clinic II, Medical University of Innsbruck, Innsbruck, Austria
Walter J. Wurzer: Speciality Pharma Service Austria, Altenmarkt, Austria
Werner Streif: Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria

DOI: https://doi.org/10.3389/fmed.2022.794456
Journal volume & issue: Vol. 9

Abstract

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ObjectiveTo review the current knowledge on bone health in patients with hemophilia A and the underlying pathogenetic mechanisms.Data SourcesOriginal research articles, meta-analyses, and scientific reviews.Data SynthesisAlready in childhood, patients with hemophilia A are prone to low bone mineral density, leading to osteopenia and/or osteoporosis. Initially associated with the life style of hemophilia, today we are faced with accumulating evidence that coagulation factor VIII is involved directly or indirectly in bone physiology.ConclusionUnderstanding the role of factor VIII and the mechanisms of decreased bone mineral density in hemophilia A is critically important, especially as non-factor replacement therapies are available, and treatment decisions potentially impact bone health.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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