Nature Communications (Apr 2021)
A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment
- Ryo Kinoshita-Daitoku,
- Kotaro Kiga,
- Masatoshi Miyakoshi,
- Ryota Otsubo,
- Yoshitoshi Ogura,
- Takahito Sanada,
- Zhu Bo,
- Tuan Vo Phuoc,
- Tokuju Okano,
- Tamako Iida,
- Rui Yokomori,
- Eisuke Kuroda,
- Sayaka Hirukawa,
- Mototsugu Tanaka,
- Arpana Sood,
- Phawinee Subsomwong,
- Hiroshi Ashida,
- Tran Thanh Binh,
- Lam Tung Nguyen,
- Khien Vu Van,
- Dang Quy Dung Ho,
- Kenta Nakai,
- Toshihiko Suzuki,
- Yoshio Yamaoka,
- Tetsuya Hayashi,
- Hitomi Mimuro
Affiliations
- Ryo Kinoshita-Daitoku
- Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University
- Kotaro Kiga
- Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Masatoshi Miyakoshi
- Division of Biomedical Science, Faculty of Medicine, University of Tsukuba
- Ryota Otsubo
- Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University
- Yoshitoshi Ogura
- Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University
- Takahito Sanada
- Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University
- Zhu Bo
- Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Tuan Vo Phuoc
- Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University
- Tokuju Okano
- Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Tamako Iida
- Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Rui Yokomori
- Human Genome Center, The Institute of Medical Science, The University of Tokyo
- Eisuke Kuroda
- Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University
- Sayaka Hirukawa
- Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Mototsugu Tanaka
- Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Arpana Sood
- Division of Bacteriology, Department of Infectious Diseases Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
- Phawinee Subsomwong
- Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University
- Hiroshi Ashida
- Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Tran Thanh Binh
- Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University
- Lam Tung Nguyen
- Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University
- Khien Vu Van
- Department of GI Endoscopy, 108 Central Hospital
- Dang Quy Dung Ho
- Department of Endoscopy, Cho Ray Hospital
- Kenta Nakai
- Human Genome Center, The Institute of Medical Science, The University of Tokyo
- Toshihiko Suzuki
- Department of Bacterial Pathogenesis, Infection and Host Response, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Yoshio Yamaoka
- Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University
- Tetsuya Hayashi
- Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University
- Hitomi Mimuro
- Department of Infection Microbiology, Research Institute for Microbial Diseases, Osaka University
- DOI
- https://doi.org/10.1038/s41467-021-22317-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Long-term infection of the stomach with Helicobacter pylori can cause gastric cancer. Here, Kinoshita-Daitoku et al. show that a small non-coding RNA of H. pylori regulates bacterial adaptation to the stomach environment and bacterial oncoprotein production.
