Nature Communications (Apr 2016)

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination

  • Changsheng Du,
  • Yanhui Duan,
  • Wei Wei,
  • Yingying Cai,
  • Hui Chai,
  • Jie Lv,
  • Xiling Du,
  • Jian Zhu,
  • Xin Xie

DOI
https://doi.org/10.1038/ncomms11120
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Current treatments of multiple sclerosis are aimed at immunosuppression. Here the authors show that kappa opioid receptor is important for oligodendrocyte differentiation and myelination and the receptor agonists are protective in a mouse model of multiple sclerosis.