Modulating protein quality control

eLife (Jul 2016)

Affiliations

Lars Plate: ORCiD; Department of Chemistry, The Scripps Research Institute, La Jolla, United States; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States
Ryan J Paxman: ORCiD; Department of Chemistry, The Scripps Research Institute, La Jolla, United States
R Luke Wiseman: ORCiD; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, United States
Jeffery W Kelly: Department of Chemistry, The Scripps Research Institute, La Jolla, United States; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States

Abstract

Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.