1,3-Dipolar Cycloaddition (Part I): Synthesis of 1,2,3-Triazole Derivatives in Nucleoside Chemistry

Abstract

Copper catalysed Huisgen 1,3-dipolar cycloaddition of azides and alkynes which leads to 1,4-disubstituted-1,2,3-triazoles is a frequently used method in synthetic organic chemistry. Due to the simple reaction conditions, it has occupied an important place in the field of nucleoside chemistry since it enables preparation of a large number of potentially biologically active compounds with a number of interesting additional properties induced by the presence of 1,2,3-triazole structural motif in the molecule.

Keywords

• Click chemistry
• nucleosides
• 1
• 2
• 3-triazole nucleoside analogs