Romanian Neurosurgery (Jun 2022)
Study of association of serum vitamin D and serum calcium with spontaneous aneurysmal subarachnoid haemorrhage in a tertiary care centre
Abstract
Background: Aneurysmal subarachnoid haemorrhage (aSAH) is a disease associated with high mortality and morbidity. Recent studies have postulated a correlation between Vitamin D deficiency and aSAH, however, the mechanism of which remains obscure. Vitamin D and Calcium in patients withaSAH has not been formally investigated. Therefore, the aim of this study was to evaluate the incidence of hypovitaminosis D and hypocalcemia in patients with aSAH. Methods: An observational study was conducted at the Department of Neurosurgery at tertiary care centre, New Delhi, India. 40 patients with spontaneous aneurysmal SAH were enrolled during the period January 2019 to 15th April 2020. The standard protocol of care was given to all patients included in the study. Laboratory investigations including Vitamin D and Calcium levels; Clinical examination and grading were done for each patient. The data thus collected was used to see the clinic-demographic profile of patients of aSAH with an emphasis on Vitamin D and Calcium levels. Results: The study reported mean vitamin D level of 17.4 ± 7 ng/ml; mean calcium level of 8.3 ± 0.9 mg/dl amongst the study participants. Out of 40 patients, 8 patients (20%) were severely deficient, 24 patients (60%) were mild to moderate deficient and 8 patients (20%) were having normal vitamin D levels. 50% of the patients (n=20) were hypocalcaemic and 50% were normocalcaemic. Conclusion: A higher incidence of vitamin D deficiency was observed in our study along with an equal incidence of hypocalcemia vs normocalcemia. Further studies with a comparison group and a bigger sample size are needed to validate this evidence.
