Frontiers in Cell and Developmental Biology (Mar 2020)

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

  • Anu Laulajainen-Hongisto,
  • Anu Laulajainen-Hongisto,
  • Sanna Katriina Toppila-Salmi,
  • Sanna Katriina Toppila-Salmi,
  • Annika Luukkainen,
  • Robert Kern

DOI
https://doi.org/10.3389/fcell.2020.00204
Journal volume & issue
Vol. 8

Abstract

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Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.

Keywords