Cells (Jun 2023)

Conditional Reprogramming Modeling of Bladder Cancer for Clinical Translation

  • Danyal Daneshdoust,
  • Ming Yin,
  • Mingjue Luo,
  • Debasish Sundi,
  • Yongjun Dang,
  • Cheryl Lee,
  • Jenny Li,
  • Xuefeng Liu

DOI
https://doi.org/10.3390/cells12131714
Journal volume & issue
Vol. 12, no. 13
p. 1714

Abstract

Read online

The use of advanced preclinical models has become increasingly important in drug development. This is particularly relevant in bladder cancer, where the global burden of disease is quite high based on prevalence and a relatively high rate of lethality. Predictive tools to select patients who will be responsive to invasive or morbid therapies (chemotherapy, radiotherapy, immunotherapy, and/or surgery) are largely absent. Patient-derived and clinically relevant models including patient-derived xenografts (PDX), organoids, and conditional reprogramming (CR) of cell cultures efficiently generate numerous models and are being used in both basic and translational cancer biology. These CR cells (CRCs) can be reprogrammed to maintain a highly proliferative state and reproduce the genomic and histological characteristics of the parental tissue. Therefore, CR technology may be a clinically relevant model to test and predict drug sensitivity, conduct gene profile analysis and xenograft research, and undertake personalized medicine. This review discusses studies that have utilized CR technology to conduct bladder cancer research.

Keywords