Nature Communications (Mar 2018)
Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein
Abstract
Glycoprotein G of vesicular stomatitis virus (VSV) enables viral entry by binding to the major VSV receptor LDL-R. Here the authors present crystal structures of G in complex with two distinct CR domains of LDL-R, identifying structural determinants for VSV infectivity in mammalian and insect cells.