Nature Communications (Mar 2018)

Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein

  • Jovan Nikolic,
  • Laura Belot,
  • Hélène Raux,
  • Pierre Legrand,
  • Yves Gaudin,
  • Aurélie A. Albertini

DOI
https://doi.org/10.1038/s41467-018-03432-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Glycoprotein G of vesicular stomatitis virus (VSV) enables viral entry by binding to the major VSV receptor LDL-R. Here the authors present crystal structures of G in complex with two distinct CR domains of LDL-R, identifying structural determinants for VSV infectivity in mammalian and insect cells.