Jichu yixue yu linchuang (Jan 2022)
Research progress on mechanism of Schwann cells promoting peripheral nerve regeneration
Abstract
Schwann cells (SCs) have a strong plasticity. After peripheral nerve injury, Schwann cells dedifferentiate into repair phenotype and dominate the repair process. C-Jun N-terminal kinase, mitogen activated protein kinase(MAPK) and other signaling pathways and transcriptional regulators are involved in regulating Schwann cell-mediated repair process. This review discusses the main signaling pathways and transcriptional regulators of Schwann cell promoting peripheral nerve regeneration.
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