Морфологія (Jan 2007)
The influence of subacute sidnocarb treatment on cateholamine concentration in the structures of central nervous system.
Abstract
The psychos stimulators are known to be able to excite catecholamine mechanisms in the nervous system, in particular to increase freeing of catecholamine from presynaptic completions. The purpose of work was an estimation of changes of catecholamine (adrenalin and noradrenalin) in the structures of cerebrum after sidnocarb treatment in the conditions of ex-periment on 48 Vistar rats. The model of the proof pathological state of cerebrum for rats was created by intrastomach intro-duction of sidnocarb in the dose of 5 mg/kg 2 times per a day during 14 days. The concentration of adrenalin and noradrenalin in the structures of brain was determined by flyuorometric method. The frontal area of neocortex, striate body, medialis part of talamus, pons and hypocampus were chose. The accumulation of adrenalin was observed in hypocampus and medialis part of thalamus by the 3rd day, the increase of concentration was on 26,1% and 43,9% correspondly. The considerable increase of adrenalin concentration in the striate body have been determined (on 76,7%) and in the neocortex (in 2,2 times). By the 14th day of sidnocarb treatment the level of adrenalin in the pons was lower on 48,1% that in control animals. Thus, the changes of noradrenalin concentration during the development of experimental psyxosis by sidnocarb treatment were significant and had different character.
