Nature Communications (Jun 2019)

Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

  • Meaghan Boileau,
  • Margret Shirinian,
  • Tenzin Gayden,
  • Ashot S. Harutyunyan,
  • Carol C. L. Chen,
  • Leonie G. Mikael,
  • Heather M. Duncan,
  • Andrea L. Neumann,
  • Patricia Arreba-Tutusaus,
  • Nicolas De Jay,
  • Michele Zeinieh,
  • Katya Rossokhata,
  • Yelu Zhang,
  • Hamid Nikbakht,
  • Carine Mouawad,
  • Radwan Massoud,
  • Felice Frey,
  • Rihab Nasr,
  • Jean El Cheikh,
  • Marwan El Sabban,
  • Claudia L. Kleinman,
  • Rami Mahfouz,
  • Mark D. Minden,
  • Nada Jabado,
  • Ali Bazarbachi,
  • Kolja Eppert

DOI
https://doi.org/10.1038/s41467-019-10705-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

The role of histone mutations in leukemogenesis remains largely unexplored. In this study of AML, the authors show that histone mutations are early events that drive a more aggressive phenotype.