Gradient light interference microscopy for 3D imaging of unlabeled specimens

Tan H. Nguyen; Mikhail E. Kandel; Marcello Rubessa; Matthew B. Wheeler; Gabriel Popescu

doi:10.1038/s41467-017-00190-7

Nature Communications (Aug 2017)

Gradient light interference microscopy for 3D imaging of unlabeled specimens

Tan H. Nguyen,
Mikhail E. Kandel,
Marcello Rubessa,
Matthew B. Wheeler,
Gabriel Popescu

Affiliations

Tan H. Nguyen: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Mikhail E. Kandel: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign
Marcello Rubessa: Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Matthew B. Wheeler: Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign
Gabriel Popescu: Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-017-00190-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 9

Abstract

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Challenges in biological imaging include labeling, photobleaching and phototoxicity, as well as light scattering. Here, Nguyen et al. develop a quantitative phase method that uses low-coherence interferometry for label-free 3D imaging in scattering tissue.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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