Impaired peroxisomal import in Drosophila oenocytes causes cardiac dysfunction by inducing upd3 as a peroxikine

Abstract

Aging is the major risk factor for cardiovascular diseases due to chronic, low-grade inflammation stemmed from pro-inflammatory factors circulating in the body. Here, the authors identify a role of hepatocyte specific peroxisomal import in mediating non-autonomous regulation of cardiac aging, through upregulation of IL6-like inflammatory cytokine.