The retinal ipRGC-preoptic circuit mediates the acute effect of light on sleep

Abstract

The preoptic area (POA) is critical for sleep regulation but its role in acute, non-circadian, light effects on sleep are unclear. The authors show that intrinsically photosensitive retinal ganglion cells provide substantial input into the POA and through these modulate the amount of non-rapid eye movement (NREM) sleep.