Influence of nanosized magnetite on the contractile activity of smooth muscle segments of the pulmonary artery of guinea pigs

Abstract

This study investigates the contractile activity of smooth muscle segments of guinea pig pulmonary artery by the method of mechanografy and morphological picture of lungs, airways and blood vessels of the pulmonary circulation under the influence of nanosized magnetite. It is shown that chronic inhalation intake of magnetite nanoparticles has a cytotoxic effect, leading to inflammatory changes in the airways, lung parenchyma and pulmonary vessels, as well as a change in contractile activity of the pulmonary artery by the action of neurotransmitters and mediators of exercising their functions under physiological conditions or produced during the inflammatory the process.

Keywords

• smooth muscle cells
• pulmonary artery
• nanoparticles
• signaling
• inflammation