Validation of Vancomycin Area under the Concentration—Time Curve Estimation by the Bayesian Approach Using One-Point Samples for Predicting Clinical Outcomes in Patients with Methicillin-Resistant <i>Staphylococcus aureus</i> Infections
Takashi Ueda,
Yoshio Takesue,
Kazuhiko Nakajima,
Kaoru Ichiki,
Kaori Ishikawa,
Kumiko Yamada,
Toshie Tsuchida,
Naruhito Otani,
Yoshiko Takahashi,
Mika Ishihara,
Shingo Takubo,
Hiroki Ikeuchi,
Motoi Uchino,
Toshimi Kimura,
Kazuaki Matsumoto,
Kazutaka Oda,
Takeshi Kimura
Affiliations
Takashi Ueda
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Yoshio Takesue
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Kazuhiko Nakajima
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Kaoru Ichiki
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Kaori Ishikawa
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Kumiko Yamada
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Toshie Tsuchida
Department of Infection Control and Prevention, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Naruhito Otani
Department of Public Health, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Yoshiko Takahashi
Department of Pharmacy, Hyogo College of Medicine Hospital, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Mika Ishihara
Department of Pharmacy, Hyogo College of Medicine Hospital, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Shingo Takubo
Department of Pharmacy, Hyogo College of Medicine Hospital, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Hiroki Ikeuchi
Department of Surgery, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Motoi Uchino
Department of Surgery, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Toshimi Kimura
Department of Pharmacy, Tokyo Women’s Medical University Hospital, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan
Kazuaki Matsumoto
Division of Pharmacodynamics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
Kazutaka Oda
Department of Pharmacy, Kumamoto University Hospital, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan
Takeshi Kimura
Department of Pharmacy, Hyogo College of Medicine Hospital, 1-1, Mukogawa-cho, Nishinomiya 663-8501, Japan
Area under the concentration–time curve (AUC)-guided vancomycin treatment is associated with decreased nephrotoxicity. It is preferable to obtain two samples to estimate the AUC. This study examined the usefulness of AUC estimation via trough concentration (Cmin)-only sampling of 260 adults infected with methicillin-resistant Staphylococcus aureus (MRSA) who received vancomycin. The exact Cmin sampling time was used for Bayesian estimation. A significantly higher early treatment response was observed in patients with a day 2 AUC ≥ 400 µg·h/mL than those with min measurement. However, assessment with two samples might be required in patients with q24 administration or high/moderate-risk MRSA infections.
