TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance

Acong Yang; Xavier Bofill-De Ros; Ryan Stanton; Tie-Juan Shao; Patricia Villanueva; Shuo Gu

doi:10.1038/s41467-022-32969-8

Nature Communications (Sep 2022)

TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance

Acong Yang,
Xavier Bofill-De Ros,
Ryan Stanton,
Tie-Juan Shao,
Patricia Villanueva,
Shuo Gu

Affiliations

Acong Yang: RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute
Xavier Bofill-De Ros: RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute
Ryan Stanton: RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute
Tie-Juan Shao: RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute
Patricia Villanueva: RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute
Shuo Gu: RNA Mediated Gene Regulation Section; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute

DOI: https://doi.org/10.1038/s41467-022-32969-8
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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