Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

Tina M. Thornton; Pilar Delgado; Liang Chen; Beatriz Salas; Dimitry Krementsov; Miriam Fernandez; Santiago Vernia; Roger J. Davis; Ruth Heimann; Cory Teuscher; Michael S. Krangel; Almudena R. Ramiro; Mercedes Rincón

doi:10.1038/ncomms10553

Nature Communications (Jan 2016)

Inactivation of nuclear GSK3β by Ser389 phosphorylation promotes lymphocyte fitness during DNA double-strand break response

Tina M. Thornton,
Pilar Delgado,
Liang Chen,
Beatriz Salas,
Dimitry Krementsov,
Miriam Fernandez,
Santiago Vernia,
Roger J. Davis,
Ruth Heimann,
Cory Teuscher,
Michael S. Krangel,
Almudena R. Ramiro,
Mercedes Rincón

Affiliations

Tina M. Thornton: Department of Medicine/Immunobiology, University of Vermont
Pilar Delgado: B Cell Biology Lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Liang Chen: Department of Immunology, Duke University Medical Center
Beatriz Salas: Department of Medicine/Immunobiology, University of Vermont
Dimitry Krementsov: Department of Medicine/Immunobiology, University of Vermont
Miriam Fernandez: Department of Medicine/Immunobiology, University of Vermont
Santiago Vernia: Program in Molecular Medicine, University of Massachusetts
Roger J. Davis: Program in Molecular Medicine, University of Massachusetts
Ruth Heimann: Department of Medicine/Radiology, University of Vermont
Cory Teuscher: Department of Medicine/Immunobiology, University of Vermont
Michael S. Krangel: Department of Immunology, Duke University Medical Center
Almudena R. Ramiro: B Cell Biology Lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Mercedes Rincón: Department of Medicine/Immunobiology, University of Vermont

DOI: https://doi.org/10.1038/ncomms10553
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Double stranded DNA breaks are generated during rearrangements of lymphocyte antigen receptors. Here the authors show that the DNA breaks induce phosphorylation of nuclear GSK3β at Ser389/Thr390, protecting the activated lymphocytes from necroptosis-mediated cell death.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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