Pifu-xingbing zhenliaoxue zazhi (Dec 2020)

Serum D-dimer and IL-33 in patients with chronic urticaria

  • Chang-qing XIAO,
  • Li-qian PENG,
  • Hua-ping LI,
  • Run-xiang LI,
  • Zhen-jie LI,
  • Hui-lan ZHU

DOI
https://doi.org/10.3969/j.issn.1674-8468.2020.06.004
Journal volume & issue
Vol. 27, no. 6
pp. 397 – 399,404

Abstract

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Objective: To explore the levels and clinical characteristics of serum D-dimer and IL-33 in patients with chronic urticaria. Methods: A total of 63 patients with chronic urticarial were divided into a positive group and a negative group according to the results of the autologous serum skin test, in addition, a normal control group was set. The levels of serum D-dimer and IL-33 were measured by ELISA in all three groups. Results: Of the 63 patients with chronic urticaria, 37 were positive for ASST, 26 were negative for ASST. Serum levels of D-dimer and IL-33 in patients with chronic urticaria of the positive group were significantly higher than that in normal controls (all P0.05). Conclusion: The levels of D-dimer are high in patients with chronic urticaria, the levels of IL-33 are high in positive group, and these elevated D-dimer and IL-33 may lead to the imbalance of the immune system and increase the occurrence and development of chronic urticaria.

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