Hyperuricemia in Destabilization of Endothelial Function in Adolescents with Arterial Hypertension

Abstract

The objective of this work was to study the correlation of uric acid level in blood serum and parameters of endothelial function and non-specific inflammation in adolescents with arterial hypertension considering their body weight. In the most of patients with arterial hypertension endothelial dysfunction was detected; endothelium-dependent vasodilation was more altered in the patients with obesity and especially in those with hyperuricemia. An increase in C-reactive protein serum level was mainly associated with obesity; a decrease in systolic-diastolic ratio — with hyperuricemia.

Keywords

• adolescents
• arterial hypertension
• hyperuricemia
• endothelial dysfunction