Cuprous oxide-based nanocrystals with combined chemo/chemodynamic therapy to increase tumor drug sensitivity by reducing mitochondria-derived adenosine-triphosphate
Haoran He,
Jiaming Wu,
Min Liang,
Yao Xiao,
Xuejian Wei,
Yuqin Cao,
Zhiheng Chen,
Tian Lin,
Miaosheng Ye
Affiliations
Haoran He
The Second People’s Hospital of Nanhai District, Guangdong Provincial People’s Hosptial’s Nanhai Hospital, Foshan, Guangdong Province, China
Jiaming Wu
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China
Min Liang
Department of Oncology, Innovation Centre for Advanced Interdisciplinary Medicine, Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong Province, China
Yao Xiao
Department of Oncology, Innovation Centre for Advanced Interdisciplinary Medicine, Guangzhou Key Laboratory of Enhanced Recovery after Abdominal Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong Province, China
Xuejian Wei
The Second People’s Hospital of Nanhai District, Guangdong Provincial People’s Hosptial’s Nanhai Hospital, Foshan, Guangdong Province, China
Yuqin Cao
The Second People’s Hospital of Nanhai District, Guangdong Provincial People’s Hosptial’s Nanhai Hospital, Foshan, Guangdong Province, China
Zhiheng Chen
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China
Tian Lin
Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
Miaosheng Ye
The Second People’s Hospital of Nanhai District, Guangdong Provincial People’s Hosptial’s Nanhai Hospital, Foshan, Guangdong Province, China
Gastrointestinal (GI) tumor is a serious disease with high mortality rates and morbidity rates worldwide. Chemotherapy is a key treatment for GI, however, systematic side effects and inevitable drug resistance complicate the situation. In the process of therapy, P-glycoprotein (P-gp) could remove chemotherapy drugs from cells, thus causing multi-drug resistance. Chemodynamic therapy (CDT) utilizing Fenton chemistry has been used for cancer therapy, along with various combination therapies. The reactive oxygen species produced by CDT could inhibit P-gp’s efflux pump function, which reduce chemoagents excretion and reverse drug resistance. In the present study, we developed novel nanocrystals (Cu2O@Pt NCs) to overcome drug resistance by reducing mitochondria-derived ATP through chemo/CDT in GI cancer. Furthermore, in vivo results in tumor-bearing mice demonstrated that treatment with Cu2O@Pt NCs with CDT and chemotherapy could achieve the most effective antitumor therapeutic effect with the least amounts of adverse effects. As a result, Cu2O@Pt NCs could provide a promising strategy for chemo/CDT-synergistic therapy.
