Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs

Abstract

Complexes of transition metals [Co(II), Cd(II) and Mo(0)] with a new enaminone (PA) 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one were synthesized and afterwards characterized by 1H NMR, 13C NMR, FAB-MS, UV–Vis, ICP-OES, TGA and FTIR. The spectroscopic and conductance data suggested that the ligand (PA) is attached to the metal ions in bidentate, neutral form through the nitrogen atom of amino group and the oxygen of carbonyl group. Metal complexes displayed octahedral geometries. In vitro urease inhibition and cytotoxic activities of all the compounds were evaluated. Results revealed that Co(II) complex (PA-Co) was even more significant than the reference drug thiourea. Analysis of the cytotoxicity indicated that, the Co(II) complex has more cytotoxic effect than enaminone ligand and other complexes when assessed on the human cancer cell lines MCF-7.Molecular docking simulation was also performed to find out the putative binding mode within the target protein.

Keywords

• Anti-urease activity
• Cytotoxicity
• Enaminone
• Metal complexes