Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review

Tara Talaie, MD, MS; Laura DiChiacchio, MD, PhD; Nikhil K. Prasad, MB, ChB; Chetan Pasrija, MD; Walker Julliard, MD; David J. Kaczorowski, MD; Yunge Zhao, MD, PhD; Christine L. Lau, MD

doi:10.1097/TXD.0000000000001104

Transplantation Direct (Feb 2021)

Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review

Tara Talaie, MD, MS,
Laura DiChiacchio, MD, PhD,
Nikhil K. Prasad, MB, ChB,
Chetan Pasrija, MD,
Walker Julliard, MD,
David J. Kaczorowski, MD,
Yunge Zhao, MD, PhD,
Christine L. Lau, MD

Affiliations

Tara Talaie, MD, MS: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Laura DiChiacchio, MD, PhD: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Nikhil K. Prasad, MB, ChB: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Chetan Pasrija, MD: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Walker Julliard, MD: 2 Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA.
David J. Kaczorowski, MD: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Yunge Zhao, MD, PhD: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
Christine L. Lau, MD: 1 Department of Surgery, University of Maryland Medical Center, Baltimore, MD.

DOI: https://doi.org/10.1097/TXD.0000000000001104
Journal volume & issue: Vol. 7, no. 2
p. e652

Abstract

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Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients.

Published in Transplantation Direct

ISSN: 2373-8731 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: http://journals.lww.com/transplantationdirect/Pages/default.aspx

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