Metachronous retinoblastoma and neuroblastoma

Ameer Kakaje, MD; Osama Hosam Aldeen, MD; Yousef Mahmoud, MD; Othman Hamdan, MD, PhD

doi:10.1016/j.epsc.2020.101386

Journal of Pediatric Surgery Case Reports (Mar 2020)

Metachronous retinoblastoma and neuroblastoma

Ameer Kakaje, MD,
Osama Hosam Aldeen, MD,
Yousef Mahmoud, MD,
Othman Hamdan, MD, PhD

Affiliations

Ameer Kakaje, MD: Damascus University, Faculty of Medicine, Damascus, Syria; Corresponding author.
Osama Hosam Aldeen, MD: Damascus University, Faculty of Medicine, Damascus, Syria
Yousef Mahmoud, MD: Damascus University, Faculty of Medicine, Damascus, Syria
Othman Hamdan, MD, PhD: Department of Haematology, Children's University Hospital, Damascus University, Damascus, Syria

DOI: https://doi.org/10.1016/j.epsc.2020.101386
Journal volume & issue: Vol. 54

Abstract

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Retino- and neuroblastoma are primitive neuroectodermal tumors which share common histology, and embryological origin. However, no apparent correlation was found that can link them both such as common genes. Our patient had retinoblastoma which was surgically treated with low-dose chemotherapy. After three years, he evolved a neuroblastoma despite the chances for this concurrence being less than 1 in 10 billion for having both tumors in one patient. Therefore, a link was speculated with the chemotherapy as the patient might previously have a favorable, undetectable neuroblastoma and transformation occurred. Nevertheless, this is the second case in which a neuro- and retinoblastoma concurred. Keywords: Retinoblastoma, Neuroblastoma, Transformation

Published in Journal of Pediatric Surgery Case Reports

ISSN: 2213-5766 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pediatrics; Medicine: Surgery
Website: https://www.sciencedirect.com/journal/journal-of-pediatric-surgery-case-reports

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